KDM6B Overexpression Cooperates with TET2 Deficiency in Chronic Myelomonocytic Leukemia. KDM6B Overexpression Cooperates with TET2 Deficiency in Chronic Myelomonocytic Leukemia

We report the RNA-Seq results including uniquely altered RNA expression and associated biological signals in BM LSK cells from mice and BM CD34+ cells from human CMML that carry both KDM6B overexpression and Tet2 deficiency Overall design: examining overall RNA expression alterations in BM LSK cells from mice carrying both KDM6B overexpression and Tet2 deficiency

本研究报道了同时携带KDM6B过表达与Tet2缺陷的小鼠骨髓（Bone Marrow, BM）LSK细胞，以及人类慢性粒单核细胞白血病（Chronic Myelomonocytic Leukemia, CMML）患者骨髓CD34⁺细胞的RNA测序（RNA-Sequencing, RNA-Seq）结果，涵盖特异性差异RNA表达谱与相关生物学信号。整体实验设计：分析同时携带KDM6B过表达与Tet2缺陷的小鼠骨髓LSK细胞的整体RNA表达变化。