Research data supporting: Germline pathogenic variants in PALB2 and other cancer-predisposing genes in families with hereditary diffuse gastric cancer without CDH1 mutation: a whole-exome sequencing study

Whole exome sequencing (WES) was performed on DNA extracted from blood obtained as part of the Familial Gastric Cancer Study. Analysis was performed across 39 individuals, both affected and unaffected, from 22 CDH1-NPV families that fulfil the international criteria for HDGC. Data includes an annotated VCF file, an md5 file and sample information. TXT files of data analysed with scripts on https://github.com/elliefewings/Fewings_2017_Gastric_Aug17

本研究针对家族性胃癌研究（Familial Gastric Cancer Study）中采集的血液提取的DNA，开展了全外显子组测序（Whole Exome Sequencing, WES）。研究共纳入22个符合国际遗传性弥漫性胃癌（Hereditary Diffuse Gastric Cancer, HDGC）诊断标准的CDH1-NPV家系中的39名受累及未受累个体，并完成了相关测序分析。数据集包含经注释的变异呼叫格式（Variant Call Format, VCF）文件、md5校验文件以及样本信息文件；此外还包含通过https://github.com/elliefewings/Fewings_2017_Gastric_Aug17平台上的分析脚本处理得到的TXT格式数据文件。