Data_Sheet_3_Towards international collaboration of clinical research networks for EMDR: the EMDR Pain Network Germany.PDF

BackgroundEye Movement Desensitization and Reprocessing (EMDR) is an evidence-based treatment, primarily established for post-traumatic stress disorder (PTSD). While it is increasingly being applied to chronic pain, its efficacy in this area is not yet supported by the same level of evidence as that which exists for PTSD. Studies in this area often show heterogeneous results with small case numbers, and the potential side effects of EMDR in the treatment of chronic pain are not well understood. Systematic documentation of treatment effects, potential predictors of treatment response and non-response, and side effects is crucial for progress in this field.
AimThe primary aim is to establish a research framework to systematically investigate the delivery of EMDR therapies by outpatient clinicians in the field of pain. This study aims to provide a comprehensive analysis of treatment outcomes, side effects and determinants of treatment effectiveness, whether positive response or non-response.
MethodsThis framework will oversee the documentation and evaluation of EMDR interventions delivered in outpatient settings using an Embedded Continuous Cumulative Evaluation Design (ECCED). It will focus on detailed characterisation of positive and negative therapeutic effects. It will also identify and analyse prognostic factors that influence individual variability in response to treatment. Treatment materials, standardised assessments and an intervision platform for regular exchange will be provided.
DiscussionThe establishment of the EMDR Pain Network Germany and an interdisciplinary scientific-clinical platform is essential to promote clinical exchange and understanding of the effects of EMDR in pain therapy. This platform offers standardised treatment protocols, an online data collection system with anonymised data, comprehensive baseline assessments and an intervision platform for regular exchange. The knowledge gained is intended to personalise future therapies and serve as a basis for large randomised clinical trials.

背景
眼动脱敏与再加工疗法（Eye Movement Desensitization and Reprocessing，EMDR）是一项以创伤后应激障碍（Post-traumatic Stress Disorder，PTSD）为核心适应症的循证治疗方案。尽管该疗法正日益广泛地应用于慢性疼痛领域，但其在该场景下的疗效尚未获得与PTSD适应症同等层级的循证证据支持。当前该领域的研究普遍存在样本量偏小、结果异质性较强的问题，且EMDR用于慢性疼痛治疗时的潜在不良反应尚未得到充分阐释。对治疗效果、治疗应答与无应答的潜在预测因素，以及不良反应进行系统性记录，对该领域的研究进展至关重要。

研究目标
本研究的核心目标是构建一套研究框架，以系统性调研疼痛领域门诊临床医师实施EMDR治疗的实践情况。本研究旨在全面分析治疗结局、不良反应，以及影响治疗应答（无论为阳性应答还是无应答）效果的决定因素。

研究方法
该研究框架将依托嵌入式持续累积评估设计（Embedded Continuous Cumulative Evaluation Design，ECCED），对门诊场景下实施的EMDR干预措施进行记录与评估。研究将重点对正负向治疗效应进行精细化表征分析，同时识别并分析影响个体治疗应答差异的预后因素。本研究将提供标准化治疗材料、标准化评估工具，以及用于定期交流的团体督导平台。

讨论
德国EMDR疼痛网络（EMDR Pain Network Germany）与跨学科科研-临床平台的搭建，对于推动临床交流以及加深对EMDR在疼痛治疗中疗效的认知至关重要。该平台将提供标准化治疗方案、匿名化在线数据采集系统、全面的基线评估工具，以及用于定期交流的团体督导平台。本研究获取的成果将用于实现未来治疗的个性化，并可为大型随机对照临床试验提供研究基础。