mRNAs and LncRNA microarray of HBE cell exposed to Al2O3 NPs, PM2.5, DEP. mRNAs and LncRNA microarray of HBE cell exposed to Al2O3 NPs, PM2.5, DEP

mRNAs and LncRNAs have been implicated in the regulation of a board range of biological processes including development, immunity and inflammation We used mRNA and LncRNA microarray to explore the detailed biological processes and mechanisms underlying matter-induced pulmonary toxicity Overall design: Microarray expression screening was performed using HBE cells exposed to PBS, Al2O3 NPs, PM2.5, DEP.

信使RNA（mRNA）与长链非编码RNA（LncRNA）已被证实参与调控包括发育、免疫及炎症在内的广泛生物学过程。本研究采用mRNA与LncRNA微阵列芯片，探究物质诱导肺毒性背后的具体生物学过程与分子机制。实验设计：以暴露于磷酸盐缓冲液（PBS）、三氧化二铝纳米颗粒（Al₂O₃ NPs）、PM2.5及柴油颗粒物（DEP）的人类支气管上皮细胞（HBE）为样本，开展微阵列表达谱筛查。