RNA mass spectrometry on WT, Tet2 KO, and Tet1/2/3 tKO mouse embryonic stem cells

Mass spectrometry for total, size selected small RNAs (< 200 nts), and gel-purified tRNAs in wild type, Tet2 single KO, and Tet1/2/3 triple KO mouse embryonic stem cells. As shown in Fig. 4A–B and Extended Data Fig. 4D of "TET2 chemically modifies tRNAs and regulates tRNA fragment levels" by He et al.

本数据集针对野生型、Tet2单基因敲除（knockout, KO）及Tet1/2/3三基因敲除的小鼠胚胎干细胞，对总RNA、经大小筛选的小RNA（<200核苷酸）以及凝胶纯化的转运RNA（transfer RNA, tRNA）进行了质谱法（mass spectrometry）分析。相关结果可见于He等人发表的论文《TET2 chemically modifies tRNAs and regulates tRNA fragment levels》中的图4A-B与扩展数据图4D。