How stress mediators can cumulatively contribute to Alzheimer’s disease An allostatic load approach

ABSTRACT. Allostatic load is defined as the frequent activation of the neuroendocrine, immunological, metabolic and cardiovascular systems, which makes individuals more susceptible to stress-related health problems. According to this model, physiological dysregulations start to emerge decades before diseases manifest. Consequently, stress research has shifted its attention to anticipating the degree of this dysregulation to better understand the impact of stress hormones and other biomarkers on disease progression. In view of the growing number of studies that demonstrate the influence of modifiable risk factors on cognitive decline, in addition to the effects of chronic stress mediators, the objective of the present review was to present an overview of the development of cognitive changes based on studies on stress and its mediators.

摘要：稳态负荷（allostatic load）被定义为神经内分泌、免疫、代谢与心血管系统的频繁激活，该状态会使个体更易罹患与应激相关的健康问题。根据该模型，生理失调会在疾病显现前数十年就开始出现。因此，应激研究已将研究重心转向预判此类失调的程度，以更深入地理解应激激素及其他生物标志物对疾病进展的影响。鉴于越来越多研究证实可改变风险因素对认知衰退的影响，以及慢性应激介质的作用，本综述旨在基于应激及其介质相关研究，系统概述认知变化的发生发展过程。