Available IPD datapackage for study 'Will Hydroxychloroquine Impede or Prevent COVID-19: WHIP COVID-19 Study'

This is a prospective, multi-site study designed to evaluate whether the use of hydroxychloroquine in healthcare workers (HCW), Nursing Home Workers (NHW), first responders (FR), and Detroit Department of Transportation bus drivers (DDOT) in SE, Michigan, can prevent the acquisition, symptoms and clinical COVID-19 infection The primary objective of this study is to determine whether the use of daily or weekly oral hydroxychloroquine (HCQ) therapy will prevent SARS-CoV-2 infection and COVID-19 viremia and clinical COVID-19 infection healthcare workers (HCW) and first responders (FR) (EMS, Fire, Police, bus drivers) in Southeast Michigan. Preventing COVID-19 transmission to HCW, FR, and Detroit Department of Transportation (DDOT) bus drivers is a critical step in preserving the health care and first responder force, the prevention of COVID-19 transmission in health care facilities, with the potential to preserve thousands of lives in addition to sustaining health care systems and civil services both nationally and globally. If efficacious, further studies on the use of hydroxychloroquine to prevent COVID-19 in the general population could be undertaken, with a potential impact on hundreds of thousands of lives.

本研究为一项前瞻性多中心研究，旨在评估羟氯喹（hydroxychloroquine）能否预防密歇根州东南部（Southeast Michigan, SE Michigan）的医护人员（healthcare workers, HCW）、养老院工作人员（Nursing Home Workers, NHW）、急救人员（first responders, FR）以及底特律交通局公交司机（Detroit Department of Transportation bus drivers, DDOT）发生新冠病毒感染、出现相关症状及临床新冠感染。本研究的主要目标为明确，每日或每周口服羟氯喹（hydroxychloroquine, HCQ）疗法，能否预防密歇根州东南部的医护人员、急救人员（含急诊医疗服务（Emergency Medical Services, EMS）、消防、警务人员及公交司机）发生严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染、新冠病毒血症及临床新冠感染。阻断新冠病毒向医护人员、急救人员及底特律交通局公交司机的传播，是维持医护与急救队伍稳定的关键举措，同时可减少医疗机构内的新冠病毒传播；此举不仅有望挽救数千条生命，还能维系全国乃至全球的医疗系统与公共服务运转。若羟氯喹预防新冠感染的效果得到证实，后续可开展针对普通人群使用羟氯喹预防新冠的研究，其潜在影响可惠及数十万生命。