THERPA: A small molecule database related to prion protein regulation and prion diseases progression

Prion diseases are fatal neurodegenerative disorders that affect humans and animals. Although various small molecules have been evaluated for application in the treatment of prion diseases, none have been shown to be efficacious. Expanding our knowledge of these molecules is important for understanding of the complex mechanisms of prion diseases. To improve access to the scattered information on small molecules related to prion diseases, we built a database of therapeutic molecules associated with prion diseases (THERPA, therpa.pythonanywhere.com). THERPA includes 119 small molecules and their 283 relationships with prion diseases. THERPA is an interactive visual database and useful for improving search efficiency which can help researchers identify intrinsic small molecules that can be used for developing therapeutics for prion diseases.

朊病毒疾病（prion diseases）是一类可累及人类与动物的致命性神经退行性疾病。尽管已有多种小分子被评估用于朊病毒疾病的治疗，但目前尚未有任何小分子被证实具有确切疗效。深化对这类小分子的认知，对于阐明朊病毒疾病的复杂致病机制至关重要。为了便于获取与朊病毒疾病相关的分散小分子信息，我们构建了一款针对朊病毒疾病治疗相关分子的数据库（THERPA，therpa.pythonanywhere.com）。该数据库共收录119种小分子及其与朊病毒疾病的283条关联记录。THERPA是一款交互式可视化数据库，可有效提升检索效率，助力研究人员筛选出可用于开发朊病毒疾病治疗药物的内源性小分子。