Raw data and statistical analysis of clonogenic survival assays with MMC.

Raw values and statistical analysis of MMC sensitivity (Fig 1C). Mean values (mean) and standard deviations (SD) from three independent experiments are shown. Ordinary Two-Way ANOVA was used for multiple comparisons (****, p < 0.0001; ***, p < 0.001; **, p < 0.01; *, p < 0.1; ns, non-significant). HeLa FIT, parental HeLa FIT cell line; FJ–/–, FANCJ knock-out cell line; WT, wild-type; KR, K52R; RQ, R279Q; CS, C283S; CH, C283H; CR, C283R; MI, M299I; LF, L340F; AP, A349P.
(XLSX)

丝裂霉素C（Mitomycin C，MMC）敏感性的原始数值与统计分析（图1C）。展示了三次独立实验的平均值（mean）与标准差（standard deviation，SD）。采用普通双因素方差分析（Analysis of Variance，ANOVA）进行多重比较（****，p < 0.0001；***，p < 0.001；**，p < 0.01；*，p < 0.1；ns，无统计学显著性）。HeLa FIT为亲本HeLa FIT细胞系；FJ–/–为FANCJ基因敲除细胞系；WT为野生型；KR为K52R突变体；RQ为R279Q突变体；CS为C283S突变体；CH为C283H突变体；CR为C283R突变体；MI为M299I突变体；LF为L340F突变体；AP为A349P突变体。
（XLSX）