Comparative study between ketamine-S-dexmedetomidine and ketamine-S-midazolam-methadone in the anesthesia of capuchin monkeys (Sapajus apella)

ABSTRACT: Anesthetic protocols have been developed to obtain the most effective and safe association in wildlife. This study compared the anesthetic effects and cardiorespiratory parameters of ketamine-S (+) (10 mg/kg)/dexmedetomidine (0.020 mg/kg) (KD ) and ketamine-S (+) (10 mg/kg)/midazolam (0.5 mg/kg)/methadone (1.0 mg/kg) (KMM ) in capuchin monkeys (Sapajus apella). Eight capuchin monkeys were randomly assigned to KD (n = 4) or KMM (n = 4) to evaluate induction, immobilization, and recovery scores, heart and respiratory rate parameters, besides systolic, mean, diastolic arterial pressure and arterial blood gas. There was no difference (P = 0.56) in the quality of induction, immobilization, and anesthetic recovery between the protocols. The time for anesthetic induction was 4 ± 1 min in the KD group and 5 ± 1 min in the KMM group, and these values were statistically equal (P = 0.28). The mean immobilization time in the KD and KMM groups were 35 ± 13 and 33 ± 15 min, respectively. Heart rate was lower in animals in the KD group (P

摘要：为在野生动物中实现最有效且安全的麻醉组合，现已开发出多种麻醉方案。本研究以棕卷尾猴（Sapajus apella）为实验对象，对比了两种麻醉方案的麻醉效果与心肺参数：其一为氯胺酮-S(+) (Ketamine-S (+))（10 mg/kg）联合右美托咪定 (dexmedetomidine)（0.020 mg/kg），记为KD组；其二为氯胺酮-S(+) (Ketamine-S (+))（10 mg/kg）联合咪达唑仑 (midazolam)（0.5 mg/kg）与美沙酮 (methadone)（1.0 mg/kg），记为KMM组。将8只棕卷尾猴随机分为KD组（n=4）与KMM组（n=4），评估两组的诱导、制动与苏醒评分，心率、呼吸频率参数，以及收缩压、平均动脉压、舒张压与动脉血气指标。两种方案在诱导、制动及麻醉苏醒质量上无显著差异（P=0.56）。KD组的麻醉诱导时间为4±1分钟，KMM组为5±1分钟，两组差异无统计学意义（P=0.28）。KD组与KMM组的平均制动时间分别为35±13分钟与33±15分钟。KD组动物的心率更低（P