NORWAY BAG

The fifteen PIs associated to this proposal represent the entire crystallography community in Norway and are affiliated to the major Norwegian universities. The research interests of the PIs and their collaborators revolves around topics linked to structural biology and material sciences. We apply for beam time for single- and multi-wavelength MX, Bio-SAXS and Cryo-EM, in support of our research projects funded e.g. by the Research Council of Norway and the ERC. Examples of research projects or topics are carbohydrate-active proteins of medical or bioeconomic relevance, inhibition of DNA repair enzymes, metalloprotein function and catalysis, regulation of cell-cycle processes, enzyme discovery, antibiotic resistance/drug-discovery and neurological diseases. Our overarching aim is to use bright synchrotron sources to produce high quality science.

本提案涉及的15位首席研究员（Principal Investigator, PI）代表了挪威整个晶体学社区，且均隶属于挪威各大主要高校。这些首席研究员及其合作者的研究兴趣围绕结构生物学与材料科学相关主题展开。我们申请单波长及多波长大分子晶体学（Macromolecular Crystallography, MX）、生物小角X射线散射（Bio-SAXS）和冷冻电子显微镜（Cryo-EM）的光束时间，以支持我们由挪威研究理事会、欧洲研究理事会（ERC）等资助的研究项目。研究项目或主题示例包括具有医学或生物经济意义的碳水化合物活性蛋白、DNA修复酶抑制、金属蛋白功能与催化、细胞周期过程调控、酶发现、抗生素耐药性/药物发现以及神经系统疾病。我们的总体目标是利用高亮度同步辐射源开展高质量科学研究。