Gene expression signature of gemcitabine resistance in human gastric cancer cell line. Homo sapiens

We examined the microarray-based expression profiles of the cells to identify genes associated with gemcitabine resistance Overall design: Using a set of parental and gemcitabine resistant cell line, MKN28 and RMKN28, we studied mRNA transcription levels by microarray analysis to see if there are any of the key molecules for development of acquisition of the GEM resistance.

本研究通过检测细胞基于微阵列（microarray）的表达谱，旨在筛选与吉西他滨（gemcitabine）耐药相关的基因。整体实验设计：本研究以亲本细胞系MKN28及其吉西他滨耐药细胞系RMKN28为研究模型，通过微阵列分析检测mRNA转录水平，以期探寻参与吉西他滨耐药获得过程的关键分子。