Crystal structure of Pol theta polymerase domain in complex with compound 5
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Crystal structure of Pol theta polymerase domain in complex with compound 5 Descriptor: 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, 2-[5-bromanyl-3-cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl]oxy-~{N}-ethyl-~{N}-(3-methylphenyl)ethanamide, DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*(DDG))-3'), ... Authors: Krajewski, W.W, Turnbull, A.P, Willis, S, Charles, M, Stockley, M, Heald, R.A. Deposit date: 2022-05-19 Release date: 2022-10-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.99 Å) Cite: Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta. J.Med.Chem., 65, 2022
与化合物5结合的DNA聚合酶θ（Pol theta）聚合酶结构域的晶体结构
描述项：2',3'-双脱氧鸟苷-5'-三磷酸、2-[5-溴-3-氰基-6-甲基-4-(三氟甲基)吡啶-2-基]氧基-N-乙基-N-(3-甲基苯基)乙酰胺、DNA（5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*(DDG))-3'）……
作者：Krajewski W.W.、Turnbull A.P.、Willis S.、Charles M.、Stockley M.、Heald R.A.
提交日期：2022-05-19
发布日期：2022-10-12
最后修改日期：2024-01-31
实验方法：X射线衍射（分辨率2.99 Å）
引用文献：《人源DNA聚合酶θ的小分子体外与体内探针的发现、表征及基于结构的优化》，J.Med.Chem., 65, 2022
创建时间：
2022-05-19
