Identification of copy number variations by array comparative genomic hybridization in multi-ethnic multiple myeloma patients. Homo sapiens

The aim of this study is to identify copy number variations in multiple myeloma patients from the 3 major ethnic groups (Malays, Chinese and Indians) in Malaysia. Identification of common chromosomal aberrations and their degree of penetrance is possible by comparing the microarray data across all the samples under studied. Overall design: 63 multiple myeloma samples were analyzed. Each sample was compared against normal control (match with patient's race and gender), which was pooled from ten healthy individuals.

本研究旨在鉴定马来西亚三大族群（马来人、华人、印度人）多发性骨髓瘤（multiple myeloma）患者的拷贝数变异（copy number variations）。通过比对所有受试样本的微阵列（microarray）数据，可鉴定常见染色体畸变及其外显率水平。总体实验设计：共分析63份多发性骨髓瘤样本，每份样本均与匹配患者种族与性别的正常对照进行比对，该对照样本由10名健康个体的样本混合制备而成。