RNA-seq of mice TRAF2/Casp-8LPC-KO tumors

This model was used to study the relationship between NF-kB and PCD regulation and generated mice with combined conditional ablation of Traf2 and Caspase-8 (TRAF2/Casp-8LPC-KO) in order to block apoptosis and specifically study the role of necroptosis in Traf2-deficient hepatocytes in vivo.

本研究使用该模型探究核因子κB（NF-κB）与程序性细胞死亡（Programmed Cell Death，PCD）的调控关系，并构建了联合条件性敲除肿瘤坏死因子受体相关因子2（TRAF2）与半胱氨酸天冬氨酸蛋白酶8（Caspase-8）的基因工程小鼠（TRAF2/Casp-8LPC-KO），以阻断细胞凋亡，进而特异性探究坏死性凋亡（necroptosis）在体内Traf2缺陷肝细胞中的功能。