Transcriptome analysis reveals anti-Cancer effects of fenbendazole on ovarian cancer: in vitro and in vivo study

We reported the transcriptome profiling of FBZ-treated SKOV3 ovarian cancer cells. A total of 1747 differentially expressed genes (DEGs) were identified, including 944 downregulated and 803 upregulated genes. KEGG enrichment and reactome enrichment showed that DEGs were mainly associated with mitosis and cell cycle associated pathway The effect of Fenbendazole (FEN OR FBZ) on transcriptome of the SKOV3 cell line

本研究报道了芬苯达唑（Fenbendazole，FBZ）处理的SKOV3卵巢癌细胞的转录组谱。共鉴定出1747个差异表达基因（differentially expressed genes, DEGs），其中944个为下调基因，803个为上调基因。京都基因与基因组百科全书（Kyoto Encyclopedia of Genes and Genomes，KEGG）富集分析与Reactome富集分析结果显示，差异表达基因主要与有丝分裂及细胞周期相关通路相关。本数据集聚焦芬苯达唑（FEN/FBZ）对SKOV3细胞系转录组的调控效应。