A systematic review on hyaluronic acid coated nanoparticles: recent strategy in breast cancer management

Hyaluronic acid, a non-sulphated glycosaminoglycan has attracted its usage in the management of breast cancer. Drug-loaded nanoparticles with hyaluronic acid surface modifications show potential as a promising method for targeting and delivering drugs to the tumor site. The aim of this study was to conduct a systematic review of articles and assess the impact of hyaluronic acid coated nanoparticles on breast cancer. The various database were used for this comprehensive review. The inclusion and exclusion criteria were selected according to the PRISMA guidelines. Studies associated with characterization, <i>in vitro</i>, and <i>in vivo</i> studies were collected and subjected for further analysis. According to the inclusion criteria, 41 literature were selected for analysis. From all the studies, it was observed that the nanoparticles coated with hyaluronic acid produced better particle size, shape, zeta potential, increased <i>in vitro</i> cytotoxicity, cellular uptake, cell apoptosis, and anti-tumor effect <i>in vivo</i>. Research has shown that hyaluronic acid exhibits a higher affinity for CD44 receptors, resulting in enhanced targeted nanoparticle activity on cancer cells while sparing normal cells.

透明质酸（Hyaluronic acid）是一种非硫酸化糖胺聚糖，已被广泛应用于乳腺癌的临床诊疗。表面修饰透明质酸的载药纳米颗粒（drug-loaded nanoparticles），有望成为靶向递送药物至肿瘤部位的有效策略。本研究旨在对相关文献开展系统综述，并评估透明质酸包被纳米颗粒对乳腺癌的干预效果。本次全面综述检索了多个学术数据库，纳入与排除标准严格遵循PRISMA指南制定。本研究收集了涉及纳米颗粒表征、体外（in vitro）实验及体内（in vivo）实验的相关研究，并开展进一步分析。根据纳入标准，最终筛选出41篇文献用于本次分析。综合所有研究结果可知，透明质酸包被的纳米颗粒在粒径、形态及Zeta电位（Zeta potential）方面表现更优，同时可提升体外细胞毒性、细胞摄取能力、细胞凋亡率以及体内抗肿瘤效应。研究表明，透明质酸对CD44受体（CD44 receptor）具有更高的亲和力，可增强纳米颗粒对癌细胞的靶向活性，同时减少对正常细胞的损伤。