A Concise Construction of Polycyclic Quinolines via Annulation of ω‑Cyano-1-alkynes with Diaryliodonium Salts

A concise construction of polycyclic quinolines via intramolecular [2 + 2 + 2] annulation of ω-cyano-1-alkynes with diaryliodonium salts was realized. The process produced polycyclic quinolines in high yields with readily available staring materials and was tolerated with halogen substituents.

本研究开发了一种通过ω-氰基-1-炔烃(ω-cyano-1-alkynes)与二芳基碘鎓盐(diaryliodonium salts)的分子内[2+2+2]环化反应(intramolecular [2+2+2] annulation)简洁构建多环喹啉(polycyclic quinolines)的方法。该反应以易得的起始原料为底物，可高产率获得多环喹啉产物，且对卤素取代基具有良好的兼容性。