Effect of monocyte ATRAP deficiency on obesity

The prevalence of obesity has increased over the past 30 years and is also a major health concern, as obesity is a risk factor for a variety of diseases. Immune cells are closely involved in the development and progression of obesity pathology. However, the role of bone marrow/immune cell ATRAP in obesity pathogenesis is largely unknown. In this study, the role of immune cell ATRAP was examined using a mouse model of diet-induced obesity. We found that deficiency of bone marrow ATRAP contributes to obesity pathogenesis via changes in the polarity of adipose tissue macrophages. Furthermore, we found that genetic alterations at the monocyte level may affect macrophage polarity.

过去三十年间，肥胖的患病率持续攀升，且肥胖作为多种疾病的危险因素，已成为一项重大公共健康议题。免疫细胞与肥胖病理过程的发生与进展密切相关。然而，骨髓/免疫细胞中的ATRAP在肥胖发病机制中的作用目前尚不明晰。本研究借助饮食诱导肥胖小鼠模型，对免疫细胞ATRAP的作用进行了探究。我们发现，骨髓ATRAP缺失可通过改变脂肪组织巨噬细胞的极化状态，参与肥胖的发病进程。此外，本研究还发现，单核细胞层面的遗传改变可能会影响巨噬细胞的极化状态。