Distribution of the dermatoscopic features of melanoma of trunk and extremities according to the anatomic sub-location

Detailed analysis of the clinical and dermatoscopic characteristics of 400 melanomas located on the trunk and extremities according to the precise anatomic sublocation. This was a retrospective study that included 400 dermatoscopic images of histopathologically diagnosed melanomas arising on six different anatomic sub-locations. The dermatoscopic images of the included tumors were evaluated for presence of predefined dermatoscopic criteria. Univariate and multivariate regression analyses were performed to identify significant correlations between dermatoscopic criteria and anatomic sub-locations. Regression structures (OR=1.80) and shiny white lines (OR=2.12) were significantly more frequent in melanomas located on the upper back, as compared to all other sub-locations. Negative pigment network (OR=2.51) was more frequent in melanomas located on abdomen. Irregular dots/globules (OR=2.25) and atypical vascular pattern (OR=2.09) were associated with the location of upper extremities. Melanomas on the lower extremities displayed irregular hyperpigmented areas (OR=3.18) and prominent skin markings (OR=6.00) more frequently as compared to all other sub-locations.

本数据集针对躯干与四肢部位的400例黑色素瘤，按照精准的解剖亚部位开展临床与皮肤镜特征的详细分析。本研究为回顾性研究，纳入了源自6种不同解剖亚部位、经组织病理学确诊的黑色素瘤的400张皮肤镜图像。针对纳入肿瘤的皮肤镜图像，研究人员对预设的皮肤镜特征进行了评估。随后通过单变量与多变量回归分析，以明确皮肤镜特征与解剖亚部位间的显著相关性。与其余所有解剖亚部位的黑色素瘤相比，上背部黑色素瘤的回归结构（优势比Odds Ratio, OR=1.80）与亮白色线条（OR=2.12）的出现频率显著更高；腹部黑色素瘤的阴性色素网络（OR=2.51）出现频率更高；上肢部位黑色素瘤与不规则斑点/球状结构（OR=2.25）及非典型血管模式（OR=2.09）存在显著关联；下肢黑色素瘤相较于其余所有解剖亚部位，更常出现不规则色素沉着过度区域（OR=3.18）与显著皮肤纹理（OR=6.00）。