Expression data from mammary tumors from a generation 7 Diversity Outcross x PyMT cross. Mus musculus

Mouse genetic crosses were established between the PyMT model of metastatic breast cancer and the G7 generation of the Diversity Outcross (DO). Tumors were harvested from the animals for gene expression analysis to identify genes association with progression to distant metastatic disease. Overall design: Gene expression of 159 samples from the PyMT x Diversity Outcross were assayed on Affymetrix chips.

本研究建立了转移型乳腺癌PyMT模型与多样性远交群（Diversity Outcross，DO）第7代（G7）的小鼠遗传杂交体系。研究人员从杂交小鼠体内获取肿瘤样本，开展基因表达分析，以筛选与远端转移性疾病进展相关的基因。实验设计概述：采用Affymetrix基因芯片对PyMT与多样性远交群杂交的159份样本进行基因表达检测。