Gene expression (bulk RNA-seq) in the trigeminal ganglia of C57BL/6 and Rag1KO mice with dry eye disease. Trigeminal gene expression and adaptive immunity in dry eye disease

We performed bulk RNA-seq of trigeminal ganglia (one sample=2 trigeminal ganglia from one mouse) of 8-week-old female C57BL/6 and Rag1KO mice that underwent either sham-surgery (controls) or extraorbital lacrimal gland excision (dry eye model) 10 days before tissue harvest. There are 3 samples per group and 4 groups (2 strains and 2 treatments).

本研究针对8周龄雌性C57BL/6小鼠与Rag1KO小鼠的三叉神经节（trigeminal ganglia）开展批量RNA测序（bulk RNA-seq），单个样本取自1只小鼠的2个三叉神经节。所有受试小鼠于组织取材前10天接受两种处理：假手术（sham-surgery，作为对照组）与眶外泪腺摘除术（extraorbital lacrimal gland excision，用于构建干眼症模型（dry eye model））。本数据集共包含4组实验，对应2种小鼠品系与2种处理方式，每组设置3个生物学重复样本。