Dietary patterns, circulating miRNA expression and healthspan in the Adventist Health Study-2

We collected plasma samples from 96 cohort members with different dietary patterns including vegan, semi-vegetarian, lacto-vegetarian and non-vegetarian, and performed miRNA deep sequencing. Our study showed that vegetarian dietary pattern is modulating aging-associated circulating miRNAs in a sex-dependent manner of differential expression for certain miRNAs that may be related to a beneficial healthspan.

本研究从96名具有不同饮食模式的队列受试者中采集血浆样本，饮食模式涵盖纯素饮食（vegan）、半素食、乳类素食（lacto-vegetarian）及非素食，并对样本进行了微小RNA（miRNA）深度测序。研究结果显示，素食饮食模式可通过性别依赖的方式调控与衰老相关的循环miRNA，其中部分miRNA的差异表达或与有益健康寿命（healthspan）相关。