Regulation of cardiac cushion endocardial cells by KLF2

Comparison of differential gene expression between controls and mice that lack the transciption factor KLF2 from the cardiac endocardium following Nfatc1 Cre deletion. Overall design: E12.5 cardiac atrio-ventricular cushion mRNA profiles were generated from KLF2 fl/fl and Nfatc1 KLF2 fl/fl mice.

本研究对比了对照组小鼠，与经Nfatc1 Cre介导敲除心脏心内膜转录因子KLF2（transcription factor KLF2）的基因工程小鼠之间的差异基因表达情况。总体实验设计：从KLF2 fl/fl与Nfatc1 KLF2 fl/fl小鼠中提取E12.5胚胎时期心脏房室垫的mRNA，对其mRNA表达谱进行检测分析。