Table 5 in Chemical constituents derived from Artocarpus xanthocarpus as inhibitors of melanin biosynthesis

Table 5 Effect of selected compounds on melanin content, tyrosinase activity, and cell viability in B16F10 melanoma cells.
CompoundsCon. (µµ)Cell viability (% of control)aMelanin content (% of control)bTyrosinase activity (% of control)bControl100.0 ± 1.7100.0 ± 2.5100.0 ± 1.2OE- MSHnd121.1 ± 11.5 #120.5 ± 4.3 #1210101.0 ± 1.7105.7 ± 2.3 ⁄137.2 ± 6.1 ⁄161093.9 ± 9.5101.0 ± 8.0 ⁄117.8 ± 8.51710107.0 ± 11.076.3 ± 2.9 ⁄75.2 ± 8.8 ⁄181099.7 ± 1.970.8 ± 1.5 ⁄88.7 ± 10.1 ⁄194099.7 ± 1.992.0 ± 15.2 ⁄89.2 ± 6.8 ⁄204099.7 ± 9.4107.4 ± 10.7127.6 ± 3.6214095.2 ± 3.458.0 ± 2.2 ⁄69.2 ± 4.0⁄
Nd: not determined. Data represents the mean ± S.D. (n = 3–6). (#) <0.05 indicates significant differences from the control group. (⁄) <0.05, ** p <0.01 indicates significant differences from the OE- MSH treated group.
a Effect of compounds on cell viability of B16F10 melanoma cells.
b The inhibitory effect on melanin production and tyrosinase activity in B16F10 melanoma cells stimulated by 50 nM OE- MSH.

表5 精选化合物对B16F10黑色素瘤细胞黑色素含量、酪氨酸酶活性及细胞活力的影响。
化合物 浓度（μM） 细胞活力（以对照组百分比计）^a 黑色素含量（以对照组百分比计）^b 酪氨酸酶活性（以对照组百分比计）^b
Control 100.0 ± 1.7 100.0 ± 2.5 100.0 ± 1.2
OE-MSH nd 121.1 ± 11.5 # 120.5 ± 4.3 #
13 10 101.0 ± 1.7 105.7 ± 2.3 ⁄ 137.2 ± 6.1 ⁄
16 10 93.9 ± 9.5 101.0 ± 8.0 ⁄ 117.8 ± 8.5
17 10 107.0 ± 11.0 76.3 ± 2.9 ⁄ 75.2 ± 8.8 ⁄
18 10 99.7 ± 1.9 70.8 ± 1.5 ⁄ 88.7 ± 10.1 ⁄
19 40 99.7 ± 1.9 92.0 ± 15.2 ⁄ 89.2 ± 6.8 ⁄
20 40 99.7 ± 9.4 107.4 ± 10.7 127.6 ± 3.6
21 40 95.2 ± 3.4 58.0 ± 2.2 ⁄ 69.2 ± 4.0 ⁄
注：Nd表示未测定。数据以平均值±标准偏差（S.D.）表示（n=3~6）。(#) <0.05表示与对照组存在显著性差异；(⁄) <0.05，**p<0.01表示与OE-MSH处理组存在显著性差异。
^a 本标注代表化合物对B16F10黑色素瘤细胞细胞活力的影响。
^b 本标注代表化合物对经50 nM OE-MSH刺激的B16F10黑色素瘤细胞的黑色素生成及酪氨酸酶活性的抑制作用。