Borrelia PeptideAtlas: A proteome resource of common Borrelia burgdorferi isolates for Lyme community

Lyme disease is a result from an infection by the spirochete Borrelia burgdorferi, and is the leading vector-borne disease in North America. Due to the genomic and proteomic variability of different B. burgdorferi isolates, the study and further comparison of their proteome is key to understand the biology and infectivity of these spirochetes. Mass spectrometry-based proteomics was used to assemble peptide datasets of laboratory isolates B31, MM1, B31-ML23, and the infective isolates B31-5A4, B31-A3, and 297, as well as other public datasets, and is publicly available as the Borrelia PeptideAtlas (http://www.peptideatlas.org/builds/borrelia/). These datasets include information on total proteome, secretome, and membrane proteome of the B. burgdorferi.

莱姆病（Lyme disease）是由螺旋体伯氏疏螺旋体（Borrelia burgdorferi）感染引发的疾病，也是北美地区最主要的虫媒传染病。由于不同伯氏疏螺旋体分离株的基因组与蛋白质组存在变异，对其蛋白质组开展研究并进行比较，是解析这类螺旋体的生物学特性与感染能力的关键。本研究采用基于质谱的蛋白质组学技术，构建了实验室分离株B31、MM1、B31-ML23以及感染性分离株B31-5A4、B31-A3和297的肽数据集，并整合了其他公开数据集，相关数据以伯氏疏螺旋体肽谱数据库（Borrelia PeptideAtlas）的形式公开获取，访问网址为http://www.peptideatlas.org/builds/borrelia/。该数据集涵盖了伯氏疏螺旋体的全蛋白质组、分泌蛋白质组以及膜蛋白质组相关信息。