X-ray crystal structure of wild type HIV-1 protease in complex with GRL-121

X-ray crystal structure of wild type HIV-1 protease in complex with GRL-121 Descriptor: (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl {(2S,3R)-4-[{[2-(cyclopropylamino)-1,3-benzothiazol-6-yl]sulfonyl}(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl}carbamate, Protease Authors: Yedidi, R.S, Hayashi, H, Aoki, M, Das, D, Ghosh, A.K, Mitsuya, H. Deposit date: 2016-11-21 Release date: 2017-10-18 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency. Elife, 6, 2017

野生型HIV-1蛋白酶（HIV-1 protease）与GRL-121复合的X射线晶体结构。配体描述：(3S,3aR,5R,7aS,8S)-六氢-4H-3,5-亚甲基呋喃并[2,3-b]吡喃-8-基 {(2S,3R)-4-[{[2-(环丙基氨基)-1,3-苯并噻唑-6-基]磺酰}(2-甲基丙基)氨基]-3-羟基-1-苯基丁烷-2-基}氨基甲酸酯。作者：Yedidi, R.S.、Hayashi, H.、Aoki, M.、Das, D.、Ghosh, A.K.、Mitsuya, H.。存档日期：2016-11-21，发布日期：2017-10-18，最后修改日期：2023-10-04。实验方法：X射线衍射（1.8 Å）。引用文献：《一种可穿透中枢神经系统的新型蛋白酶抑制剂，以空前的阿托摩尔至皮摩尔级活性克服人类免疫缺陷病毒1型耐药性》，《eLife》，第6卷，2017年。