Expanding the spectrum of CNS EWSR1-PATZ1 rearranged tumors: an infantile case with leptomeningeal dissemination

This case shows similarities with 2 previously reported cases, including intraventricular location, histologic appearance (pushing borders, oligodendrocyte-like morphology, rich vascular network) and immunophenotype with co-expression of OLIG2, GFAP and synaptophysin. The onset in an infant, the presence of a high-grade component and the leptomeningeal dissemination, however, have not been previously reported in EWSR1-PATZ1 rearranged tumors, expanding the clinico-pathological spectrum. One Tumor sample was analyzed

本病例与2例既往报道的病例具有相似特征，包括病变位于脑室内、组织学形态（推挤性边界、少突胶质细胞样形态、丰富的血管网）以及共表达OLIG2、GFAP和突触素（synaptophysin）的免疫表型。然而，婴儿起病、存在高级别成分以及软脑膜播散这几点，在既往报道的EWSR1-PATZ1重排肿瘤中均未被提及，本研究拓展了该类肿瘤的临床病理谱。本次研究对1例肿瘤样本进行了分析。