RNA-sequence reads of embryonic tooth germs from the domestic cat, Felis catus

In this study we investigated the genetic differences between three distinct types of teeth (incisor, canine, and premolar) during embryonic development in the domestic cat, Felis catus. Incisor, canine, and premolar teeth differ in the shape and size of the tooth crown in domestic cats and in many other mammals, including humans. Tooth development has been well-studied in laboratory mice, however, mice lack canines and premolars, therefore relatively little is known about the development of different tooth types within the embryo. To address this, we performed RNA-sequencing of dental tissues from deciduous incisor, canine, and premolar teeth to identify genetic differences between each of these tooth types during embryonic development.

本研究以家猫（Felis catus）为研究对象，探究了其胚胎发育过程中三种不同类型牙齿——门齿（incisor）、犬齿（canine）与前臼齿（premolar）之间的遗传差异。在家猫及包括人类在内的诸多哺乳动物中，门齿、犬齿与前臼齿的齿冠形态与尺寸均存在差异。尽管实验室小鼠的牙齿发育已被广泛研究，但小鼠天生缺失犬齿与前臼齿，因此学界对胚胎阶段不同牙齿类型的发育机制所知相对有限。为填补这一研究空白，本研究对乳牙门齿、犬齿及前臼齿的牙组织开展RNA测序（RNA-sequencing），以鉴定胚胎发育阶段不同牙齿类型之间的遗传差异。