Fig. 2 HPV-human Protein Network Map

Network representation of the HPV-human interaction map in C33A cells (see also Supplementary Table S2). Diamond shaped nodes represent the 9 individually expressed HPV-31 proteins and circles represent the 137 high-confidence human interactors. HPV-human interactions are depicted in solid black lines, and manually curated human-human interactions are shown with broken grey lines.

In the downloadable file, interactors are colored based on detection in HEK293 (blue), Het-1A (orange) or both (see also Supplementary Table S2, Supplementary Fig. S1 and S2). Green rings around interactors indicate previously described HPV-human PPIs (see also Supplementary Table S1). Cancer genes are highlighted by a broken red ring around the respective human prey node.

C33A细胞中人乳头瘤病毒（Human Papillomavirus，HPV）-人类互作图谱的网络可视化结果（详见补充表S2）。菱形节点代表9种单独表达的HPV-31病毒蛋白，圆形节点则代表137个高可信度的人类互作蛋白。人乳头瘤病毒与人类间的互作以黑色实线表示，而经人工整理验证的人类自身蛋白互作关系则以灰色虚线展示。
在可下载文件中，互作蛋白的配色依据其在HEK293细胞、Het-1A细胞中的检测情况而定：仅在HEK293细胞中检测到的标记为蓝色，仅在Het-1A细胞中检测到的标记为橙色，同时在两种细胞中均检测到的则采用对应混合配色（详见补充表S2、补充图S1与S2）。互作蛋白外围的绿色环圈代表此前已报道的人乳头瘤病毒-人类蛋白质相互作用（Protein-Protein Interaction，PPI，复数PPIs）（详见补充表S1）。对应人类靶蛋白节点外围的红色虚线环，则用于高亮标注癌症基因。