Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency. Mus musculus

Here we delineate the roles of RNA binding for WDR5 function on chromatin state and murine embryonic stem cell (ESC) maintenance. Overall design: Examination of global transcriptional changes and mapping genome-wide transcription factors occupancy at distinct time points during the transdifferentiation process

本研究阐明了RNA结合对于WDR5在染色质状态调控与小鼠胚胎干细胞（ESC）维持过程中的功能作用。实验设计概述：在转分化过程的不同时间节点下，检测全转录组表达变化，并绘制全基因组范围转录因子结合占据图谱。