HDAC2 interacts with ELAVL1 to activate Caspase 1/IL-1β pathway

WB confirmed that HDAC2 and ELAVL1 bound to each other in the KOA model, WB confirmed that the levels of ELAVL1 and Caspase1 proteins increased, and qPCR confirmed that the HDAC2 and ELAVL1 complex could enhance the stability of Caspase1 mRNA.

Western Blot（WB）证实，在KOA模型中HDAC2与ELAVL1存在相互结合；WB同时显示ELAVL1和Caspase1蛋白水平显著升高；此外，定量聚合酶链式反应（qPCR）验证了HDAC2与ELAVL1复合物能够增强Caspase1 mRNA的稳定性。