Exosomal miRNA sequencing of blood samples from normal and preeclampsia pregnant women

Preeclampsia (PE) is a gestational hypertensive disorder, which affects approximately 5% of pregnant women, is one of the most important complications during pregnancy and a leading cause of maternal morbidity and mortality. The precise aetiology of preeclampsia is still not fully understood until now. Therefore, we performed exosomal miRNA sequencing of blood samples from normal and PE pregnant women aim to provide new perspectives for the prediction and treatment of PE and new bio-markers for diagnosis of PE.

子痫前期（Preeclampsia, PE）是一类妊娠高血压疾病，约影响5%的妊娠女性，是妊娠期最关键的并发症之一，同时也是孕产妇发病与死亡的首要诱因。截至目前，子痫前期的确切病因仍未完全阐明。为此，本研究对正常妊娠及子痫前期孕妇的血液样本开展了外泌体微小核糖核酸（microRNA, miRNA）测序，旨在为子痫前期的预测与治疗提供全新视角，并为其诊断发掘新型生物标志物（bio-marker）。