Relationship between insulin sensitivity and gene expression in human skeletal muscle (Study B). Relationship between insulin sensitivity and gene expression in human skeletal muscle (Study B)

We studied 9 healthy young non-diabetic men without any family history of diabetes. The mean age and body mass index (BMI) were 25.33 ± 0.33 years and 24.57 ± 0.62 kg/m2, respectively, and the mean 1/ homeostatic model assessment of insulin resistance (HOMA-IR) was 1.17 ± 0.12. We included baseline gene expression profile data (i.e. only before bed rest) Overall design: The aim of this study was to investigate molecular mechanisms associated with insulin sensitivity in skeletal muscle by relating global skeletal muscle gene expression with a surrogate measure of insulin sensitivity, i.e. homeostatic model assessment of insulin resistance (HOMA-IR)

本研究纳入9名健康年轻的非糖尿病男性受试者，所有受试者均无糖尿病家族史。受试者的平均年龄与体质量指数（body mass index, BMI）分别为25.33±0.33岁与24.57±0.62 kg/m²，其胰岛素抵抗稳态模型评估（homeostatic model assessment of insulin resistance, HOMA-IR）的倒数均值为1.17±0.12。本研究包含卧床休息前的基线基因表达谱数据。研究整体设计：本研究旨在通过将骨骼肌全局基因表达与胰岛素抵抗的替代指标——胰岛素抵抗稳态模型评估（HOMA-IR）相关联，探究骨骼肌胰岛素敏感性相关的分子机制。