Data_Sheet_1_Regional homogeneity alterations in multifrequency bands in patients with basal ganglia stroke: A resting-state functional magnetic resonance imaging study.PDF

ObjectiveThe aim of this study was to investigate the spontaneous regional neural activity abnormalities in patients with acute basal ganglia ischemic stroke (BGIS) using a multifrequency bands regional homogeneity (ReHo) method and to explore whether the alteration of ReHo values was associated with clinical characteristics.
MethodsIn this study, 34 patients with acute BGIS and 44 healthy controls (HCs) were recruited. All participants were examined by resting-state functional magnetic resonance imaging (rs-fMRI). The ReHo method was used to detect the alterations of spontaneous neural activities in patients with acute BGIS. A two-sample t-test comparison was performed to compare the ReHo value between the two groups, and a Pearson correlation analysis was conducted to assess the relationship between the regional neural activity abnormalities and clinical characteristics.
ResultsCompared with the HCs, the patients with acute BGIS showed increased ReHo in the left caudate and subregions such as the right caudate and left putamen in conventional frequency bands. In the slow-5 frequency band, patients with BGIS showed decreased ReHo in the left medial cingulum of BGIS compared to the HCs and other subregions such as bilateral caudate and left putamen. No brain regions with ReHo alterations were found in the slow-4 frequency band. Moreover, we found that the ReHo value of left caudate was positively correlated with the NIHSS score.
ConclusionOur findings revealed the alterations of ReHo in patients with acute BGIS in a specific frequency band and provided a new insight into the pathogenesis mechanism of BGIS. This study demonstrated the frequency-specific characteristics of ReHo in patients with acute BGIS, which may have a positive effect on the future neuroimaging studies.

研究目的：本研究旨在采用多频段区域同质性（regional homogeneity, ReHo）分析方法，探究急性基底节缺血性脑卒中（acute basal ganglia ischemic stroke, BGIS）患者的自发性脑区神经活动异常特征，并探讨ReHo值的改变是否与患者临床特征存在关联。研究方法：本研究共纳入34例急性BGIS患者与44例健康对照（healthy controls, HCs）。所有受试者均接受静息态功能磁共振成像（resting-state functional magnetic resonance imaging, rs-fMRI）扫描。采用ReHo方法分析急性BGIS患者的自发性脑区神经活动改变情况；通过两独立样本t检验比较两组间的ReHo值差异，并采用Pearson相关分析评估脑区神经活动异常与临床特征之间的相关性。研究结果：与健康对照相比，急性BGIS患者在常规频段下的左侧尾状核、右侧尾状核及左侧壳核等亚脑区的ReHo值显著升高。在慢5频段中，急性BGIS患者的左侧内侧扣带回及双侧尾状核、左侧壳核等亚脑区的ReHo值较健康对照显著降低；而在慢4频段中未检测到存在ReHo改变的脑区。此外，本研究发现左侧尾状核的ReHo值与美国国立卫生研究院卒中量表（National Institutes of Health Stroke Scale, NIHSS）评分呈显著正相关。研究结论：本研究揭示了急性BGIS患者在特定频段下的ReHo改变特征，为阐明BGIS的发病机制提供了全新视角。本研究明确了急性BGIS患者ReHo的频段特异性表现，可为未来相关神经影像学研究提供有益参考。