Additional file 3 of Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden

Additional file 3. Supplementary Tables. The associations between epigenetic measures of ageing and disease phenotypes in the discovery cohort (Bonferroni-corrected threshold: P < 2.54 x 10-4; significant results are emboldened). (Table S1). The associations between epigenetic measures of ageing and continuous phenotypes in the discovery cohort (Bonferroni-corrected threshold: P < 2.54 x 10-4; significant results are emboldened). (Table S2). The associations between epigenetic measures of ageing and all-cause mortality in the discovery cohort (Bonferroni-corrected threshold: P < 2.54 x 10-4; significant results are emboldened). (Table S3). Associations between significant phenotypes (identified in the discovery set) and epigenetic measures of ageing in the replication cohort at P < 6.41 x 10-4. (Table S4). Discovery Cohort: Associations between phenotypes (significant in basic model) and epigenetic measures of ageing in a fully-adjusted model (Bonferroni threshold: P < 6.41 x 10-4). (Table S5). Replication Cohort: Associations between phenotypes (significant in basic model) and epigenetic measures of ageing in a fully-adjusted model (Bonferroni threshold: P < 6.41 x 10-4). (Table S6). Covariate-specific analyses of trait-epigenetic age relationship attenuation in the discovery cohort. (Table S7). Covariate-specific analyses of trait-epigenetic age relationship attenuation in the replication cohort. (Table S8). The associations between epigenetic measures of ageing calculated at study baseline and ICD-10-coded incident disease data in Generation Scotland in a basic model adjusted for age and sex. Significant associations that survived a multiple testing correction threshold of 8.33 x 10-4 (0.05/60 tests) are emboldened. Nominally significant associations are italicised. (Table S9). The associations between epigenetic measures of ageing measured at study baseline and ICD-10-coded incident disease data in Generation Scotland in a fully-adjusted model adjusted for age, sex and common disease risk factors. Significant associations that survived a multiple testing correction threshold of 8.33 x 10-4 (0.05/60 tests) are emboldened. Nominally significant associations are italicised. (Table S10). Sex-specific differences in categorical phenotype-epigenetic age relationships within the discovery cohort. (Table S11).

附加文件3：补充表格。发现队列（discovery cohort）中表观遗传衰老指标（epigenetic measures of ageing）与疾病表型的关联分析（邦费罗尼（Bonferroni）校正阈值：P < 2.54 × 10⁻⁴；显著性结果以加粗形式呈现）（表S1）。发现队列中表观遗传衰老指标与连续型表型的关联分析（邦费罗尼校正阈值：P < 2.54 × 10⁻⁴；显著性结果以加粗形式呈现）（表S2）。发现队列中表观遗传衰老指标与全因死亡率（all-cause mortality）的关联分析（邦费罗尼校正阈值：P < 2.54 × 10⁻⁴；显著性结果以加粗形式呈现）（表S3）。复制队列（replication cohort）中由发现集筛选得到的显著性表型与表观遗传衰老指标的关联分析（P < 6.41 × 10⁻⁴）（表S4）。发现队列：以全校正模型（fully-adjusted model）分析基础模型中具有显著性的表型与表观遗传衰老指标的关联（邦费罗尼校正阈值：P < 6.41 × 10⁻⁴）（表S5）。复制队列：以全校正模型分析基础模型中具有显著性的表型与表观遗传衰老指标的关联（邦费罗尼校正阈值：P < 6.41 × 10⁻⁴）（表S6）。发现队列中表型-表观遗传衰老关联的协变量特异性衰减分析（表S7）。复制队列中表型-表观遗传衰老关联的协变量特异性衰减分析（表S8）。苏格兰世代队列（Generation Scotland）中，以校正年龄与性别的基础模型分析研究基线时检测的表观遗传衰老指标与ICD-10（国际疾病分类第10版）编码的新发疾病数据的关联。通过多重检验校正（multiple testing correction）阈值8.33 × 10⁻⁴（0.05/60次检验）的显著性结果以加粗形式呈现，名义显著性（nominally significant）结果以斜体形式呈现（表S9）。苏格兰世代队列中，以校正年龄、性别及常见疾病危险因素的全校正模型分析研究基线时检测的表观遗传衰老指标与ICD-10编码的新发疾病数据的关联。通过多重检验校正阈值8.33 × 10⁻⁴（0.05/60次检验）的显著性结果以加粗形式呈现，名义显著性结果以斜体形式呈现（表S10）。发现队列中分类表型-表观遗传衰老关联的性别特异性差异分析（表S11）。