Comparison of choroidal thickness in patients with active and stable thyroid eye disease

ABSTRACT Purpose: To compare the choroidal thickness in active and stable phases of thyroid eye disease. Methods: Forty-seven eyes of 47 patients with thyroid eye disease were prospectively studied. Patients were evaluated on the basis of their clinical activity scores, with scores 33 defined as active disease. Subfoveal, temporal macular, nasal macular, temporal peripapillary, and nasal peripapillary choroidal thickness measurements were performed with Cirrus enhanced depth imaging spectral-domain optical coherence tomography, and the results in the two groups were compared. Results: Twenty-four patients were int he active group, whereas 23 patients were in the stable group. Choroidal thickness was significantly higher in the subfoveal and temporal macular regions in the active group. Although the nasal macular and peripapillary values were also higher in the active group, the difference was insignificant. Conclusions: Subfoveal choroidal thickness was significantly higher in patients with thyroid eye disease in the active phase than in those with stable phase disease.

摘要
研究目的：比较甲状腺相关眼病（thyroid eye disease）活动期与稳定期的脉络膜厚度。
研究方法：前瞻性纳入47名甲状腺相关眼病患者的47只眼开展研究。依据患者的临床活动度评分进行分组，以评分≥3定义为活动性疾病。采用Cirrus增强深度成像光谱域光学相干断层扫描（Cirrus enhanced depth imaging spectral-domain optical coherence tomography）分别测量中心凹下、颞侧黄斑、鼻侧黄斑、颞侧视盘旁及鼻侧视盘旁的脉络膜厚度，并对比两组的测量结果。
研究结果：最终活动性疾病组纳入24名患者，稳定期疾病组纳入23名患者。活动性疾病组的中心凹下及颞侧黄斑区域脉络膜厚度显著升高。尽管活动性疾病组鼻侧黄斑及视盘旁区域的脉络膜厚度也更高，但差异无统计学意义。
研究结论：甲状腺相关眼病活动期患者的中心凹下脉络膜厚度显著高于稳定期患者。