Epigenetic Regulation of Nuclear Lamina-Associated Heterochromatin by HAT1 and the Acetylation of Newly Synthesized Histones [ChIP-seq]

We report that HAT1 regulates chromatin accessibility of large chromosomal domains that correspond to regions of high H3K9 methylation density. Overall design: Examination of H3 K9me2 and H3 K9me3 histone marks in mouse immortalized mouse embryonic fibroblasts.

本研究报道，组蛋白乙酰转移酶1（HAT1）可调控对应于高H3K9甲基化密度区域的大型染色体结构域的染色质可及性。实验整体设计：在永生化小鼠胚胎成纤维细胞中检测H3K9me2与H3K9me3两种组蛋白修饰标记。