Genome-wide chromatin accessibility profiles of TET2-disrupted T cells from a chronic lymphocytic leukemia (CLL) patient.. Genome-wide chromatin accessibility profiles of TET2-disrupted T cells from a chronic lymphocytic leukemia (CLL) patient.

Following CD19-directed chimeric antigen receptor (CAR) T cell infusion, TET2 disrupted CAR+ T cells exhibited an epigenetic profile consistent with altered differentiation. Overall design: Epigenetic profiling of CAR+ and CAR- CD8+ T cells and examination of chromatin landscape changes associated with TET2 dysfuction using lymphocytes expanded from a CLL patient.

经CD19靶向嵌合抗原受体（chimeric antigen receptor, CAR）T细胞输注后，TET2功能受损的CAR+ T细胞呈现出与分化异常相符的表观遗传特征。
整体实验设计：本研究采集慢性淋巴细胞白血病（Chronic Lymphocytic Leukemia, CLL）患者的扩增淋巴细胞，对CAR+与CAR- CD8+ T细胞进行表观遗传谱分析，并探究与TET2功能异常相关的染色质景观变化。