Susceptibility to ceftazidime/avibactam in German MDR/XDR Pseudomonas aeruginosa. Susceptibility to ceftazidime/avibactam in German MDR/XDR Pseudomonas aeruginosa

In this study, we assessed the ceftazidime/avibactam (CZA) susceptibility rates, compared gradient and disk diffusion tests with broth microdilution for CZA susceptibility testing and studied the clonal structure and antimicrobial resistance genes in 192 multidrug and extensively drug resistant clinical P. aeruginosa isolates.

本研究针对192株多重耐药及广泛耐药临床分离铜绿假单胞菌（Pseudomonas aeruginosa, P. aeruginosa），评估了菌株对头孢他啶/阿维巴坦（ceftazidime/avibactam, CZA）的敏感率，对比梯度药敏试验、纸片扩散法与肉汤微量稀释法用于CZA药敏检测的性能，并分析了该菌株群的克隆结构与抗菌药物耐药基因。