CPT1A Over-expression Increases Reactive Oxygen Species in the Mitochondria and Promotes Antioxidant Defenses in Prostate Cancer

The goal of this study was to identify gene expression changes and pathways associated with CPT1A deficiency ( knockdown, KD) and overexpression (OE) of prostate cancer cells RNA-seq was used to define the effects of CPT1A knokdown (KD) or overexpression (OE) on gene expression in LNCaP-C4-2 castration resistant prostate cancer cells

本研究旨在鉴定与前列腺癌细胞肉碱棕榈酰转移酶1A（CPT1A）缺陷（即敲低，KD）及过表达（OE）相关的基因表达变化及通路。本研究采用RNA测序（RNA-seq）技术，明确CPT1A敲低或过表达对LNCaP-C4-2去势抵抗性前列腺癌细胞基因表达的影响。