Genetically determined metabotypes with the strongest signal of association.

Reported are the SNP identifier (rs number), chromosome, chromosomal position, the minor allele frequency (MAF), the metabolic trait with the lowest p-value of association (test against the null-hypothesis of no association), and percentage of the variance explained by the additive genetic model. Association results for metabolic traits with pTables 2, S2, S3, S4, and S5. Data for all 363 metabolic traits are available as supporting online data (Datasets S1 and S2). P-values of association from previous GWA studies for the same SNP (neighboring SNP rs1200826 for ANKRD30A) are reported for the following traits: (a) HDL cholesterol, LDL cholesterol, triglycerides are from the publication of Willer et al. [6]; (b) 2 h glucose, 2 h insulin, apolipoproteins A-I, A-II, B, total cholesterol, fasting glucose, fasting insulin, HOMA insulin resistance, insulinogenic index are from the Diabetes Genetics Initiative (DGI) study [5]; (c) bipolar disorder, coronary artery disease, Crohn's disease, hypertension, rheumatoid arthritis, type 1 and type 2 diabetes mellitus are from the WTCCC study [7]. Associations with p-values larger than 0.1 are indicated by a ��-��.

本数据集报告了单核苷酸多态性（Single Nucleotide Polymorphism, SNP）标识符（rs编号）、染色体信息、染色体位置、次要等位基因频率（Minor Allele Frequency, MAF）、关联P值最低的代谢性状（针对无关联的零假设开展显著性检验），以及加性遗传模型所解释的方差占比。代谢性状的关联结果详见表2及补充附表S2、S3、S4、S5。全部363个代谢性状的数据集可作为在线补充数据获取（数据集S1与S2）。针对下述性状，报告了既往全基因组关联（Genome-Wide Association, GWA）研究中对应SNP（ANKRD30A的邻近SNP rs1200826）的关联P值：(a) 高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯的数据来自Willer等人[6]的研究；(b) 2小时血糖、2小时胰岛素、载脂蛋白A-I、A-II、B、总胆固醇、空腹血糖、空腹胰岛素、HOMA胰岛素抵抗指数、胰岛素生成指数的数据来自糖尿病遗传学倡议（Diabetes Genetics Initiative, DGI）研究[5]；(c) 双相情感障碍、冠状动脉疾病、克罗恩病、高血压、类风湿关节炎、1型与2型糖尿病的数据来自Wellcome Trust病例对照研究联盟（WTCCC）[7]。P值大于0.1的关联以‘†-‡’标注。