Linkage of genetic drivers and strain-specific germline variants confound mouse cancer genome analyses

Cell cultures were isolated from primary pancreatic cancers (PPTs) of KPC mice and subjected to array comparative genomic habridization (aCGH) for the investigation of copy nummber profiles. We generated primary pancreatic cancer cell cultures from KPC mice (n=4). Investigated mouse genotypes are: KPC (n=4).

本研究从KPC小鼠的原发性胰腺癌（PPTs）中分离细胞培养物，并采用阵列比较基因组杂交（array comparative genomic hybridization, aCGH）技术对其拷贝数谱进行分析。我们从4只KPC小鼠中构建了原发性胰腺癌细胞培养体系，本次研究所涉及的小鼠基因型为KPC（n=4）。