Table_1_Association between weight-adjusted waist index and arterial stiffness in hypertensive patients: The China H-type hypertension registry study.doc

ObjectiveExploring the relationship between (weight-adjusted waist index) WWI and arterial stiffness (AS) in the total and different BMI populations among patients with hypertension.
MethodsThis study enrolled 5232 hypertensive subjects, a subset of the China H-type Hypertension Registry Study. WWI was calculated as WC (cm) divided by the square root of weight (kg). Brachial-ankle pulse wave velocity (baPWV) was measured to determine AS.
ResultsThe mean WWI was 10.97 (0.78)cm/√kg. In multiple logistic analyses showed that there were significant dose-dependent association between WWI with baPWV in a dose-dependent manner in total population (β 57.98, 95% CI 44.06-71.90), and in different BMI group: group 1 (BMI<18.5kg/m2) (β 94.30, 95% CI 39.36-149.23), group 2 (18.5-23.9kg/m2) (β 74.21, 95% CI 54.57-93.85), group 3 (≥24kg/m2) (β 26.11, 95% CI 5.22-47.01). In stratified analysis, stronger associations between WWI and baPWV were observed in patients with higher BP or lower BMI. Sensitivity analysis by excluding patients treated with lipid-lowering agents did not change the association between WWI and baPWV.
ConclusionFor hypertensive patients, we found that WWI was positively associated with baPWV in different BMI groups. WWI might be considered as an intervening factor in preventing and treatment of AS, besides BP management.

研究目的：探讨高血压患者总体人群及不同体质量指数（body mass index, BMI）亚组中，体重调整腰围指数（weight-adjusted waist index, WWI）与动脉僵硬度（arterial stiffness, AS）的关联。
研究方法：本研究纳入中国H型高血压登记研究的5232名高血压受试者。WWI计算公式为腰围（waist circumference, WC，单位：cm）除以体质量（kg）的平方根。通过检测臂踝脉搏波传导速度（brachial-ankle pulse wave velocity, baPWV）评估动脉僵硬度。
研究结果：研究对象的平均WWI为10.97（0.78）cm/√kg。多因素logistic回归分析显示，在总体人群中，WWI与baPWV呈显著剂量依赖关联（β=57.98，95%CI：44.06~71.90）；在不同BMI亚组中亦存在该关联：亚组1（BMI<18.5kg/m²，β=94.30，95%CI：39.36~149.23）、亚组2（18.5kg/m²~23.9kg/m²，β=74.21，95%CI：54.57~93.85）、亚组3（BMI≥24kg/m²，β=26.11，95%CI：5.22~47.01）。分层分析结果显示，在血压水平更高或体质量指数更低的高血压患者中，WWI与baPWV的关联更强。排除服用调脂药物的受试者进行敏感性分析后，WWI与baPWV的关联未发生显著改变。
研究结论：本研究发现，在不同BMI亚组的高血压患者中，WWI均与baPWV呈正相关。除血压管理外，WWI或可作为预防与治疗动脉僵硬度的干预靶点。