LncRNA CHROME regulates the interferon response to viral challenge [COVID]. LncRNA CHROME regulates the interferon response to viral challenge [COVID]

Long non-coding RNAs (lncRNAs) are important regulators of the immune response. Here we identify a novel function for the primate-specific lncRNA, CHROME. We established that CHROME is most highly transcribed in human macrophages treated with influenza virus and/or polyIC. Overall design: Whole blood RNAseq performed on subjects with COVID and controls.

长链非编码RNA（long non-coding RNAs, lncRNAs）是免疫应答的重要调控因子。本研究鉴定出了灵长类特异性长链非编码RNA CHROME的全新功能。我们证实，CHROME在经流感病毒和/或聚肌胞苷酸（polyIC）处理的人巨噬细胞中转录水平最高。实验整体设计：对新冠感染受试者与健康对照个体的全血样本进行RNA测序（RNAseq）。