Candidate SNPs associated with allergic asthma onset in a pediatric population.

Each cluster of significant SNP is represented here by the one showing the highest silhouette value. Allelic and genotypic p values are determined by individual genotyping carried out on the MassArray Sequenom platform. Biological relevance to asthma is shown by literature-based functional classification and gene expression meta-analysis of experimental asthma murine models (ovalbumin or house dust mite challenge). Results are shown by increasing values of allelic P. Complete results table, including SNPs not directly associated with Refseq genes (LD r2<0.8 on CEPH Hapmap data) are shown in Table S1–S2 in File S1.

本研究选取轮廓系数最高的单核苷酸多态性（Single Nucleotide Polymorphism, SNP）作为各显著SNP簇的代表。等位基因P值与基因型P值通过MassArray Sequenom基因分型平台开展的个体基因分型实验测定。本研究通过基于文献的功能注释分类，以及对卵清蛋白或屋尘螨致敏攻击的实验性哮喘小鼠模型进行基因表达荟萃分析，验证了相关结果与哮喘的生物学相关性。结果按等位基因P值的升序进行展示。完整结果表（包含未直接与RefSeq基因关联的SNP，即CEPH Hapmap数据中连锁不平衡（Linkage Disequilibrium, LD）r²<0.8的SNP）详见附件文件S1中的表S1至表S2。