Human Cancer Models Initiative (HCMI) Cancer Model Development Center

The Human Cancer Models Initiative (HCMI) is an international consortium that is generating novel, next-generation, tumor-derived culture models annotated with genomic and clinical data. HCMI-developed models and related data are available as a community resource. The NCI is contributing to the initiative by supporting four Cancer Model Development Centers (CMDCs). CMDCs are tasked with producing next-generation cancer models from clinical samples. The cancer models include tumor types that are rare, originate from patients from underrepresented populations, lack precision therapy, or lack ca...

人类癌症模型倡议（Human Cancer Models Initiative，HCMI）是一项国际性联合研究计划，旨在构建全新一代肿瘤源性培养模型，并为所有模型配备基因组学与临床数据注释。HCMI开发的模型及相关配套数据将作为社区共享资源对外公开。美国国家癌症研究所（National Cancer Institute，NCI）正通过支持四家癌症模型开发中心（Cancer Model Development Centers，CMDCs）参与该倡议。癌症模型开发中心的核心任务是从临床样本中制备下一代癌症模型。此类癌症模型涵盖罕见肿瘤类型、源自代表性不足群体患者的肿瘤、缺乏精准治疗方案的肿瘤，或缺乏ca……

搜集汇总

背景与挑战

背景概述

Human Cancer Models Initiative (HCMI) Cancer Model Development Center数据集提供经过临床和基因组数据注释的新型癌症模型，特别关注罕见肿瘤类型和缺乏精准治疗的癌症。数据由Genomic Data Commons (GDC)管理，每月更新，可作为社区资源使用。