Human Cancer Models Initiative (HCMI) Cancer Model Development Center

The Human Cancer Models Initiative (HCMI) is an international consortium that is generating novel, next-generation, tumor-derived culture models annotated with genomic and clinical data. HCMI-developed models and related data are available as a community resource. The NCI is contributing to the initiative by supporting four Cancer Model Development Centers (CMDCs). CMDCs are tasked with producing next-generation cancer models from clinical samples. The cancer models include tumor types that are rare, originate from patients from underrepresented populations, lack precision therapy, or lack ca...人类癌症模型倡议（Human Cancer Models Initiative，HCMI）是一项国际性联合研究计划，旨在构建全新一代肿瘤源性培养模型，并为所有模型配备基因组学与临床数据注释。HCMI开发的模型及相关配套数据将作为社区共享资源对外公开。美国国家癌症研究所（National Cancer Institute，NCI）正通过支持四家癌症模型开发中心（Cancer Model Development Centers，CMDCs）参与该倡议。癌症模型开发中心的核心任务是从临床样本中制备下一代癌症模型。此类癌症模型涵盖罕见肿瘤类型、源自代表性不足群体患者的肿瘤、缺乏精准治疗方案的肿瘤，或缺乏ca……

搜集汇总

背景与挑战

背景概述

Human Cancer Models Initiative (HCMI) Cancer Model Development Center数据集提供经过临床和基因组数据注释的新型癌症模型，特别关注罕见肿瘤类型和缺乏精准治疗的癌症。数据由Genomic Data Commons (GDC)管理，每月更新，可作为社区资源使用。