Machine Learning-Driven Discovery of STAT3 as a Pivotal Target for Wen-Wei-San-Ji Formula in Chronic Atrophic Gastritis Therapy: Multi-Omics Integration and Experimental Confirmation

This study indicated that WWSJ can inhibit the expression of STAT3 and p-STAT3(Tyr 705) proteins, suggesting that WWSJ may suppress the JAK-STAT3 signaling pathway.

本研究表明，WWSJ可抑制信号转导与转录激活因子3（STAT3）及磷酸化STAT3（酪氨酸705位点，p-STAT3(Tyr 705)）的蛋白表达，提示WWSJ可能抑制JAK-STAT3信号通路。