<b>Supporting Information files-</b><b>Oxyphenbutazone improves memory and learning impairments in LPS-induced </b><b>neurotoxicity</b><b> via modulating TGF-β/NF-κB/IκB-α pathways</b>

The objective of the current study was to assess the effect of Oxyphenbutazone on improving memory and learning impairments in LPS-induced neurotoxicity. To evaluate the impact of Oxyphenbutazone against LPS-induced neurotoxicity in rats, followed by treatment with Oxyphenbutazone (35 and 70 mg/kg, per oral) an hour before injection of LPS (1 mg/kg i.p.) for 7 days. The findings show that Oxyphenbutazone at both doses significantly improved behavioral activity and restored neurotransmitters, biochemical, and neuroinflammatory.本研究旨在评估羟布宗（Oxyphenbutazone）对脂多糖（LPS）诱导的神经毒性所致记忆与学习功能障碍的改善作用。为探究羟布宗对抗大鼠LPS诱导神经毒性的效果，实验于大鼠腹腔注射（i.p.）1mg/kg LPS前1小时，予以35mg/kg与70mg/kg剂量的羟布宗经口给药，连续给药7天。结果显示，两种剂量的羟布宗均可显著改善大鼠行为活动，并使其神经递质水平、生化指标及神经炎症状态恢复至正常水平。